As a tip, it's recommended to avoid the Sacrifice Rooms unless you have extra health you don't need or think your run might end without risking it. If you can pick up items such as Book of Belial or Lusty Blood, whose effects last the entire length you are in a room, then it will be greatly beneficial for the main arena, as you can technically stay in the room as long as you want fighting enemies before looking into the other rooms. The Shop in Greed Mode is very special, it usually is very randomized with different room layouts that could be useful depending on the situation. Then, whenever you have extra keys, be sure to open the regular Treasure Room for another item. The general strategy to completing Greed Mode easily is to always pick up the item in the opened Treasure Room that has a silver crown on the minimap. The final room will contain the Ultra Greed boss, which after you defeat you can donate coins to the Greed Machine which can unlock various things, including a new character. The final floor will then only have three rooms: the empty room you start out in, a room above that with usually a Monstro or some Greeds. After that, you move onto the next floor by heading into the room that is the most south until you reach The Shop, which will not have any treasure rooms but otherwise contain the same layout. After you defeat those, you can fight an optional eleventh wave to fight another special boss wave which will open the Devil Deal Room/Angel Room in the bottom left corner of the area.

Each new wave also counts as entering a new room, so you will get charges for any active items as you start new waves.Īfter eight waves, you will have to press the button again to fight two more waves, both of which will contain bosses. Each time you start a new wave, the game will place some coins near the button. If you don't defeat the enemies before the time ends, the next wave will spawn anyways. If you defeat a wave before the time runs out, it will automatically spawn a new wave. Pressing the button once more will stop the waves from spawning, but will deal half a heart of damage to you. The way the mode works is simple: You press a button in the main room and that spawns enemies in timed waves.

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